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On Pdazzler.net

Sunscreen Anyone?

Retinyl Palmitate & Cancer

Retinyl Palmitate is contained in over 500 brands of sunscreen.  For years scientific studies have been incriminating retinyl palmitate as being a carcinogen or cancer causing agent.  Sunday, June 13th, New York Senator Chuck Shumer asked the FDA to quit stalling and release information from these studies so the American public would be made aware.

Source: (Reuters – June 13) – A senator on Sunday called on the FDA to reveal findings on a possible link between a chemical found in most sunscreens and skin cancer. Continue reading Sunscreen Anyone?

Cancer as a metabolic disease

by: Thomas N Seyfried and Laura M Shelton

Abstract

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention.

Introduction

Professor Thomas Seyfried

Cancer is a complex disease involving numerous tempo-spatial changes in cell physiology, which ultimately lead to malignant tumors. Abnormal cell growth (neoplasia) is the biological endpoint of the disease. Tumor cell invasion of surrounding tissues and distant organs is the primary cause of morbidity and mortality for most cancer patients. The biological process by which normal cells are transformed into malignant cancer cells has been the subject of a large research effort in the biomedical sciences for many decades. Despite this research effort, cures or long-term management strategies for metastatic cancer are as challenging today as they were 40 years ago when President Richard Nixon declared a war on cancer [1,2].

Confusion surrounds the origin of cancer. Contradictions and paradoxes have plagued the field [3-6]. Without a clear idea on cancer origins, it becomes difficult to formulate a clear strategy for effective management. Although very specific processes underlie malignant transformation, a large number of unspecific influences can initiate the disease including radiation, chemicals, viruses, inflammation, etc. Indeed, it appears that prolonged exposure to almost any provocative agent in the environment can potentially cause cancer [7,8]. That a very specific process could be initiated in very unspecific ways was considered “the oncogenic paradox” by Szent-Gyorgyi [8]. This paradox has remained largely unresolved [7]. Continue reading Cancer as a metabolic disease

Cancer & Lifestyle Exposed

Grass Fed Dairy

Pdazzler readers may recall my stressing over and over the easiest way to prevent cancer and best way to assist your body in curing cancer is to recreate the lifestyle and environment your great grandparents enjoyed 100 years ago.

That virtually all chronic disease and a host of others can be traced directly to what we eat, how we exercise, the toxins we ingest and place on our bodys and the stress of modern day life.

I have been urging readers to eat organic whole foods for quite some time and recently suggesting that all with the ability go back to drinking raw, unpasturized milk.

Wouldn’t you know that hidden away in a corner of the internet is a recent study of the Amish settlements in Ohio.     No surprises, you will be impressed by the huge differences in cancer rates amoung these intellegent people who probably do live very similarly to the way their great grandparents did 100 years ago Continue reading Cancer & Lifestyle Exposed

Genomics goes beyond DNA

A technology that simultaneously reads a DNA sequence and its crucial modifications makes its debut.

By: Alla Katsnelson

DNA methylation in cancer

What makes two individuals different? Biologists now know that the genome sequence holds only a small part of the answer, and that key elements of development and disease are controlled by the epigenome — a set of chemical modifications, not encoded in DNA, that orchestrate how and when genes are expressed. But whereas faster, cheaper and more accurate sequencing technologies have developed rapidly, techniques to map the epigenome have lagged behind.

DNA polymerase (shown flanking the double helix) can reveal genomic and epigenomic detail.LAGUNA DESIGN/SPL

Sequencing company Pacific Biosciences, based in Menlo Park, California, has now developed an integrated system that simultaneously reads a genome sequence and detects an important epigenetic marker called DNA methylation. “I think it’s an important step forward, although I think it is a baby step,” says Joseph Ecker, a plant geneticist at the Salk Institute for Biological Studies in La Jolla, California, who was not involved in the work. Continue reading Genomics goes beyond DNA

Crisis in the NCI

Crisis in the National Cancer Institute

Source: Samuel S. Epstein - Huffington Post 5/03/10

National Cancer Institute

As warned in an April 25 New York Times editorial, the National Academy of Sciences has just reported that National Cancer Institute’s (NCI) system for judging the clinical effectiveness of cancer treatments is approaching “a state of crisis.” As critical, the NCI’s system for publicizing avoidable causes of cancer remains virtually non-existent, even though nearly one in two men and more than one in three women now develop cancer in their lifetimes.

On April 24, Nobel Laureate Dr. Francis Collins, director of the National Institutes of Health (NIH) appointed by President Obama on August 2009, delivered the Francis Collins Lecture in Chicago. Dr. Collins lecture focused on his landmark discoveries of the genetic basis of disease, including cancer. In reference to a question on the role of genetics in avoidable causes of cancer, he responded, “I am unaware of any avoidable causes of cancer.” Not surprisingly, President Obama still remains unaware of a wide range of avoidable causes of a wide range of cancer as summarized in a press release nearly 18 months ago. Continue reading Crisis in the NCI