How Controlled  Amino Acid Therapy (CAAT) Works
Source:  A.P. John Institute for Cancer Research

Controlled Amino Acid Therapy

The objective of CAAT is to alter or impair the development of cancer cells by interfering with the five basic requirements of cell formation (structure, energy, blood vessels, growth hormones and functions). This is accomplished by controlling the intake of the 20 different amino acids. The building blocks of proteins and cells, that the cancer cell requires for formation, growth and function. In essence, amino acids in the form of enzymes and hormones, control literally every chemical reaction that takes place in the cells of the body. (Source, text book, Practical Physiological Chemistry: authors; Harper, Rodwell and Mayes.) Thus, the name Controlled Amino Acid Therapy (CAAT).

1. Structure: It impairs the creation of certain amino acids that are essential to manufacture DNA in cancer cells. Without structure, the cancer cell can not develop.

 

2. Energy: Increases the daily intake of certain amino acids, and along with its individualized formulation manipulates the two energy systems. The differences between how cells derive their energy explains why the functionality of normal cells will not be affected, and why the shutting off of the energy supply to cancer cells, by inhibiting Glycolysis, results in starving them to death.

 

3. Blood Vessels: Reduce the body’s daily intake of certain amino acids, which prevents cancer cells from building new blood vessels. Cancer cells require more of certain amino acids because they don’t have a built-in vascular system.

 

4. Growth Factors: Reduce the over production of proteins that function as growth factors. In addition, almost all cancer cells depend upon several growth factors for their growth and reproduction. For example: the growth hormone is responsible for regulating production. A reduction in the production of the growth hormone inhibits the production of other growth factors, and thereby shuts down the process of cell division, an indirect way of eliminating cancerous cells.

 

5. Functions: It inhibits production of enzymes and hormones that are essential to their growth, reproduction and metastasis (spreading to other parts of the body).

The Scientifically Formulated Amino Acid Therapy

(Keep in mind, CAAT is much more than just a “diet”; it is an amino acid, carbohydrate, & glucose REDUCTION protocol which strategically uses the chemical reactions of amino acids, foods, and nutritional supplements to impair the development of cancer cells, thus starving them to death.) Clinical trials have already been done with humans using amino acid depravation formulas, and with much success. (Journal American Medical Association. 1967; 200:211)

CAAT is a course of therapy to control a patient’s amino acid intake. This is achieved by taking certain foods out of a persons’ daily food plan for a short time and by replacing them with a scientifically supported formula of amino acids. It is also important to emphasize that the food plan that accompanies the amino acid formula needs to be followed so not to offset any of the benefits we are creating by depriving the cancer cells the nutrients they need to grow. Also, it is important to realize that the patient does not need to abandon their conventional cancer treatment, (surgery, chemotherapy, radiation, hormone treatments) nor is it recommended that they do so unless it has already failed them. CAAT works synergistically with chemotherapy and/or radiation to enhance their benefits (see study by Dr. Marco Rabinowitz of the National Cancer Institute). His report on amino acid deprivation, such as with Controlled Amino Acid Therapy (CAAT), proven to inhibit phosphofructokinase which shuts down the energy supply to cancer cells, simultaneously enhancing the benefits of chemotherapy while lessening their toxic side effects. CAAT has also proven to work successfully alone.

Phase 1: CAAT Formulation

The most important component of CAAT is the scientifically formulated amino acids. Based on the specific formula for each cancer, it consists of separate amino acids, citric acid, and small amounts of sodium benzoate. Each formula replaces most of the regular daily proteins found in meats, dairy, fish, beans and nuts, which cancer cells can derive their energy from. The CAAT formula taken two times per day will nourish the healthy cells while causing the cancer cells to starve to death. Of course each individual has specific needs concerning their diet, and this is explained in the second phase of the protocol as well as with a specialist at the Institute when beginning the CAAT therapy.

Phase 2: Daily Food Intake

DISCLAIMER:DO NOT consume the following food plan without our amino acid formula and/or without consent from your doctor and our Institute. (This is a generic SAMPLE food plan, a personalized food plan will be created based on each patients needs)

Breakfast:
*1/2 Grapefruit or 1-orange or 6-ounces of fresh orange juice.
Whey Enhanced Protein (Vanilla Flavor – Vitamin Shoppe Brand) approximately
10 – 12 grams of protein – read label carefully]. OR 4 ounces lean meat of choice
1/2 Cup Grits (Butter, cinnamon and other spices are okay).
1 cup of green or black tea (Fructose is sweetener of choice).
* Do Not have ½ grapefruit if taking Chemotherapy

Explanation: ½ Grapefruit or 1 orange or 6 ounces of fresh orange juice are rich in the natural nutrients called Limonene and Citric Acid. Limonene helps shut down the Ras cancer gene which is over active in 90 percent of all cancers. Citric Acid helps shut down glycolosis which in turn helps starve cancer cells to death.

Whey Enhanced Protein (Vanilla Flavor – Vitamin Shoppe Brand) Phosphorus is a nutrient that cancer cells must utilize in order to grow and reproduce. This brand of whey protein is very low in phosphorous and contains no additional vitamins, so when using approximately 10 – 12 grams of protein per 150 lb. person, it helps to protect normal cells, maintain a normal appetite, and also helps to fight edema. (Edema is the swelling or water build up in the legs or other sites in the body)

Whey protein is included in the daily menu of all advanced or metastatic cancer patients. When treating cancers that are stable or have regressed in size, patients then have the option of including other protein foods at their breakfast meals such as cottage cheese, yogurt, or soy foods. Eggs are allowed in the diets of patients with lymphoma and brain cancers.

Grits or Cream of Wheat or 1 slice of white toast or ½ plain bagel or ½ English muffin (Butter is okay)

Grits or white rice is the preferred carbohydrate food at each meal. The other choices are options once the patient’s cancer is stable or reduced in size. Unrefined carbohydrates are included in the CAAT menu instead of whole grains to deprive cancer cells of a certain B-complex vitamin called Pyridoxine (Vitamin B-6). Cancer cells require this vitamin to manufacture certain amino acids that we keep away from through CAAT’s amino acid reduction formula and diet.
Grits is the preferred carbohydrate food at all meals instead of rice, corn, or pasta because it helps deplete Tryptophan in the body, which is essential for the growth and spreading of cancer cells.

1 cup of green or black tea, using fructose as the sweetener of choice. These teas are rich sources of several compounds that help shut down glycolosis and cut off the energy supply to cancer cells. Also, green or regular tea helps to prevent certain hormones and tumor growth factors from stimulating cancer cells to grow and metastasize to other parts of the body. Brassica teas can also be taken because they contain sulphorane, a nutrient that inhibits cancer growth, and also shuts down the cancer genes.
* Why we use fructose as the sweetener of choice will be explained in detail at the end of this phase of the CAAT protocol.

Lunch:

CAAT amino acid formula (4 level scoops OR 14 capsules) taken / mixed with any of the following: Water & Fructose; Sugar free Kool-Aid; Diet soda; Fresh lemonade & Fructose; Chicken or Beef broth; V8 juice.
Generous amounts of One cooked vegetable or a combination of the following: asparagus, broccoli, cabbage, brussell sprouts, spinach, squash, string beans.
1/2 Cup of fresh berries or preferred fruit. Choice of: orange, apple, blueberries, raspberries, strawberries, etc.
1/2 Cup to 1 Cup of grits or rice or pasta (Add tomato sauce or butter)
1 tablespoon of olive or coconut oil
8 to 10 black or green olives
2 tablespoons of vinegar (minimum of 5% acidity) add to vegetables or food
1 cup of green or black tea (Fructose as desired)

Explanation:

This Amino Acid Reduction Formula (4 level plastic scoops may vary) combined with the special diet, allows the CAAT Protocol to reduce certain amino acids in the daily diet of the cancer patient, and is designed to replace most of the animal protein in the diet. Cancer cells require the amino acids glycine, serine, glutamic acid, and aspartic acid to synthesize DNA, build new blood vessels or duplicate its entire contents of proteins. Also, cancer cells require these and certain other amino acids in order to synthesize other proteins that act as growth promoting hormones or tumor growth factors. CAAT impairs the synthesis of a protein called elastin, which is absolutely essential to the manufacture of new blood vessels. The Amino Acid Reduction Formula, diet, certain phytochemicals and herbs work efficaciously to attack cancer cells at each and every biological front.

The generous amounts of one cooked vegetable or a combination of such helps keep normal cells healthy. They are low in carbohydrates and proteins, and high in phytochemicals, compounds which help fight cancer. Patients are allowed to eat these vegetables and salads whenever desired.

The 8 to 10 olives are rich in squalene and oleic acid, nutrients that have been reported to inhibit certain cancer growth factors. The calories in olives also help control body weight and increases ketones in the blood. Ketones help fight cancer by impairing glycolosis – a process in which cancer cells depend almost exclusively upon for their daily supply of energy. Vinegar (and fructose) are two natural products that increase the production of both ACETIC ACID and CITRIC ACID in the body.

Acetic acid and citric acid also help fight cancer by shutting down the process of glycolosis.
Normal cells derive most of their daily energy supply from acetic acid and citric acid, where as cancer cells derive most of their daily energy from glycolosis.

Dinner:

CAAT amino acid formula (4 plastic level scoops OR 14 capsules) taken / mixed with any of the following: Water & fructose; Sugar free Kool–Ade; Diet Ginger Ale; Fresh lemonade & Fructose; Chicken or Beef broth; V8 Juice.
Generous amounts of One cooked vegetable or a combination of the following: asparagus, broccoli, cabbage, brussel sprouts, spinach, squash, string beans.
1/2 Cup of fresh berries or preferred fruit. Choice of: orange, apple, blueberries, raspberries, strawberries, etc.
Avacado salad with lettuce, tomatoes, celery, onions, with lemon juice and olive oil or olive oil.
2 tablespoons of vinegar (minimum of 5% acidity) add to vegetables or food.
1/2 up to 1 Cup of grits or polenta or rice or pasta (Add garlic and butter or tomato sauce for variety)
1 cup of green or black tea (Fructose as desired)

Mid Evening Snack: Ketogenic Cocktail – 2 ounces of fresh cream, ½ ounce each of both coconut & olive oil, 1 tablespoon of Fructose.
Sugar free Jell-O with fresh whipped cream & Fructose or 1 handful of berries or 4 ounces of orange juice.

Explanation: The sugar free jell-o helps to appease the appetite. Berries contain quinlic acid, which is converted into benzoic acid in the body and which in turn helps to deplete the availability of the amino acid Glycine (Glycine is essential to the synthesis of DNA for cancer cells) and the proteins that cancer cells require to build new blood vessels and their tumor growth factors. If underweight take two ounces of light cream and one ounce of olive oil/coconut oil as needed to maintain weight.

Optional Meal:

3 to 4 ounces of Veal, Fish of choice, Beef, Chicken breast, and 1-slice of white bread.

Consume this meal with a minimum of 3 hours before or after taking the amino acids.

Explanation: If the patient is 10 or more pounds underweight or if their albumin levels are below normal is when the optional meal is allowed. This meal should be eaten a minimum of 3 hours before or after taking the amino acids. CAAT provides sufficient protein to maintain the health of normal cells and adequate amounts of calories to maintain desired body weight. Any proteins taken in excess of amounts recommended in the diet will counter act the benefits of the CAAT protocol.

Special Diets: A special diet will be created for any cancer patient whose ability to consume food and liquids has placed them in a critical situation. When a patient is using a feeding apparatus, or they have become too weak or lethargic to eat and drink the daily minimum amount for survival, we will break up the total breakfast, lunch, and dinner over a period of every 2 hours during the entire day until the patient is capable of returning to a daily diet as outlined above.

Carbohydrate and glucose reduction in this diet: CAAT’S dietary menu provides approximately 20 percent of its calories in the form of carbohydrates. Calories need not be a focal point or counted daily. It is recommended that all patients combat their cancers by keeping their body weight at normal or slightly below normal levels. A patient’s desired body weight is regulated by their rate of metabolism, which in turn is regulated by their blood levels of thyroxine, cortisone, insulin, and the amounts of fats and oils in the diet. Studies with human cancer patients and laboratory animals show that reducing the calories of carbohydrates (glucose) in their daily diet by only 10 percent reduced the size of cancerous tumors. When carbohydrate (glucose) calories were reduced 40 percent, the cancers disappeared. It is recommended that those patients who are obese gradually and systematically lose their excess weight to increase the efficiency of the CAAT protocol. Those patients who are underweight shoudn’t gain weight unless they are more than 10 pounds below normal levels. When a patient is underweight due to anorexia or cachexia, such illnesses must be addressed before the CAAT protocol can begin.

Why we use Fructose and Vinegar to treat cancer:

Nobel Prize winner Dr. Otto Warburg discovered more than 50 years ago that all cancer cells produce inordinate amount of lactic acid but he couldn’t explain why.

In 2001 our Institute published the first study to show that cancer cells produce excess amounts of lactic acid because they could not access the oxygen in compartments in the cells called the mitochondria. This provided evidence that cancer cells depend almost exclusively upon glycolosis or the metabolism of glucose as their major source of energy.

Dr. Spitz and Dr. Lee with other cancer researchers published studies showing that when cancer cells are deprived glucose, their energy supply is cut off which causes these cancer cells to commit suicide.

Therefore shutting down glycolosis would be one means of destroying cancer cells because energy can only be derived from glucose through the metabolic process called glycolosis.

Recently our Cancer Institute discovered that both acetic acid and citric acid could inhibit the activity of a key enzyme in glycolosis called phosphofructokinase, which in turn shuts down the process of glycolosis. Our cancer Institute is the first to introduce both fructose and vinegar as treatments for cancer because they either contain or produce acetic acid.

In conclusion, fructose and vinegar are added as supplements to the CAAT protocol because of their acetic acid properties that help shut down glycolosis, shutting off cancer cells energy supply and causing them to die off.

Phase 3: Nutritional Supplements

Introduce Your Doctor to CAAT

Nutritional supplements are based on each unique situation. For example, slow growing cancers produce low levels of toxic free radicals. Tumor cells that grow aggressively produce large amounts of toxic free radicals. The patient will be instructed whether or not to take anti-oxidants (in a nutritional supplement) and at what dosage, according to the levels of toxic free radicals produced in the cancerous cells.

An example of how nutritional supplements can help manipulate cancer cells involves vitamin B-6 (pyroxidine) There are four amino acids essential to the synthesis of DNA. However, those amino acids cannot be synthesized without a certain enzyme, which includes vitamin B-6 among other components. Any supplement containing vitamin B-6 SHOULD NOT be taken during the first 2 months of the CAAT protocol.

The patient will be instructed as to which nutritional supplements or phytochemicals should be purchased and at what dosage strength. Keep in mind that each supplement only complements the CAAT protocol. However, when they are combined they augment the therapeutic benefits of the aminoacid, carbohydrate, and glucose reduction diet.

Vitamin D: Helps activate in many kinds of cancers enzymes called Phosphotases, which literally shut down the activities of other enzymes called Kinases, which are essential to the growth and reproduction of cancer cells.

Green Tea : Phytochemicals in tea help shut down glycolosis (cancer cell’s main supplier of energy) and thereby help to starve cancer cells to death. These effects help complement the effects of CAAT’S carbohydrate reduction.

Anti-Oxidants: The controversy as to whether or not to treat cancer with anti-oxidants is slowly resolving with the current understanding of how they affect the activity of genes and enzymes in cancer cells. The prevailing data shows that the benefits or lack of benefits depend upon the oxidative state the cancer cells are in. Anti-oxidants taken when the cells are in a very high oxidative state may prevent cancer cells from entering apoptosis ( apoptosis is when a cancer cell commits suicide) When oxidative stress in cancer cells is only slightly above normal, anti-oxidants are then expected to stop their growth and reproduction.

Blood Chemistry: Blood tests are usually taken every 6 to 8 weeks, depending upon the results of each test. Not only is it important to monitor the tumor markers but equally important to keep abreast of the overall health of normal tissues and organs. For example, it is important to learn of the health of the kidneys and liver, whether the body is producing sufficient red and white blood cells, etc. Low albumin levels most often indicate insufficient intake of proteins in the diet and this problem would have to be addressed. CAAT is designed to attack cancer but keep the normal cells and tissues functioning harmoniously.

Whey Protein: This protein food is recommended at the breakfast meal to help meet the daily needs of amino acids for the normal cells of the body, and to help keep albumin levels normal and to help prevent edema. We recommend Whey protein purchased from the Vitamin Shoppe because it is the only brand that we have seen with no phosphorous or additional vitamins added to it.

Grits / Rice: Grits & Rice are also recommended in place of whole grains due to their low amounts of vitamin B-6. Cancer cells require B-6 to manufacture the amino acid Glycine, which is required for DNA synthesis. Grits or Rice, instead of whole grains, therefore helps prevent cancer cells from manufacturing DNA and building new blood vessels.

Calcium D-Glucurate: This phytochemical helps the body to retain a compound called Glucuronic acid. This is necessary to eliminate both estrogen and testosterone from the body. This is why Calcium D-Glucurate is added to the regiments of patients with breast & prostate cancers. Calcium D-Glucurate is not to be confused with calcium carbonate, which is nothing more than a calcium supplement.

Tocotrienols: This member of the Vitamin E family also helps shut down Isoprenylation and assists D-Limonene in blocking the actions of the various tumor growth factors. More specifically, tocotrienols shut down an enzyme called HMG-2, that is essential to the synthesis of the building blocks that form the Isoprenylation process.

Niacin: This B-Complex vitamin works with D-limonene and the Tocotrienols to shut down the process of Isoprenylation, which as mentioned above prevents the cancer promoting RAS genes from sending signals into the nucleus of the cell. Niacin also helps deplete thee amino acid Glycine, which cancer cells need to synthesize DNA. And by reducing cholesterole in the body, Niacin helps lower the production of estrogen and testosterone.

CDP Choline: This B-complex vitamin is included in our supplement list to help the liver metabolize Niacin and other compounds and to help fight fatigue that accompanies most forms of cancer.

Selenium: Numerous studies show that this mineral can interfere with the activity of certain genes that promote the growth of cancer and to induce cancer cells to commit suicide (apoptosis)

Perilla Oil: This oil is rich in Alpha Linolenic Acid which can inhibit the growth of cancer cells in several ways. One way is to inhibit the synthesis in the body of a tumor growth promotin hormone called Prostaglandin-2, also, Alpha Linolenic Acid inhibits the actions of certain genes that promote the growth of cancer cells. Linolenic acid is not to be confused with linoleic acid, which is a bad fat that stimulates the growth of cancer cells. This bad fat, linoleic acid, is found in all vegetable oils and nuts (With the exception of coconut oil). Olive oil has the least amount of this bad fat.

Super Miraforte: This herb impairs the synthesis of estrogen from testosterone in the body and is included in the regiments of women with breast cancer.

Licorice Root Extract & Pantothenic Acid: This HERB and VITAMIN are added to the regiment when it is desirable to produce steroid like actions in the body. Used also to help patients gain weight and to inhibit the growth of Lymphomas and Leukemia’s.

Resveratrol: This phytochemical blocks the actions of a number of a number of cancer promoting genes thereby causing cancer cells to enter into apoptosis (cell death) and is included in the treatment of all cancers.

Melatonin: Numerous studies show that this hormone blocks the synthesis of the cancer promoting chemicals in the body called Leukotrienes, and is included in the treatment of all cancers.

CATT is designed to attack cancer, while keeping normal cells and tissues functioning harmoniously.

Source:  A.P. John Institute for Cancer Research

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New Documentary Empowers Cancer Patients to Take Action

"Cancer is Curable Now"

LOS ANGELES, Calif., Feb. 28, 2011 (SEND2PRESS NEWSWIRE) — “Cancer is Curable Now,” presented by Wake-Up TV, is a feature-length documentary that demonstrates the problems cancer patients face and a wide range of solutions utilizing holistic cancer treatments. It reveals patient options and busts the myth that cancer is a deadly disease.

This cancer documentary empowers patients, family members and supporters by showing how to support the body’s innate healing mechanisms.

“People need to know that they have many choices and that they can be in charge of their healing process and not be victims,” says Marcus Freudenmann, director and producer of “Cancer is Curable Now.”

“We introduce cancer treatment options that physicians usually don’t share because of pharmaceutical-industry protocol.”

Freudenmann adds, “Cancer patients are not a commodity who need more products; they need education.”

Garry F. Gordon , MD, DO, MD (H)

“Cancer is Curable Now” reveals that there are hundreds of non-toxic options that provide minimal, if any, side effects that work to reduce cancer dramatically, while greatly improving quality of life.

“We need to return to a common sense approach,” explains Freudenmann. “A pill for every ill is not always the answer and in most cases it only serves to intensify the problem.”

“Cancer is Curable Now” is an in-depth piece and seven chapters and 67 titles address all facets of healing cancer.

It teaches people how to avoid carcinogens; how to find a good holistic physician; and how to check if the physician is actually helpful or just following a standard protocol. It shows many treatments that are free of charge or cost a fraction of the cost of a single chemotherapy treatment, without destroying the immune system and yielding stunning results.

This cancer documentary also provides tools for mental and emotional healing; ways to problem solve; and tips for how to incorporate healthy habits into a lifestyle.

Produced by Marcus and Sabrina Freudenmann, the couple was motivated to release this documentary after watching a close friend die from the side effects of chemotherapy and radiation, while another friend cured herself from cancer using complementary methods.

During a world tour with their four children, the couple interviewed more than 89 doctors, scientists and practitioners in 12 countries. 30 presenters are featured in this documentary. Some top presenters include: Bruce H. Lipton, Ph.D; Leigh Erin Connealy, M.D.; Gary F. Gordon, M.D., D.O., M.D.(H); Stanislaw R. Burzynski, M.D., Ph.D; Friedrich Douwes, M.D.; Charlotte Gerson; Francisco Contreras, M.D.; and many more.

Official Trailer

www.youtube.com/watch?v=Zv3fiCbPrhc

“Cancer is Curable Now” is available at: http://www.wake-up.tv .

For more information contact:
Marcus Freudenmann, Wake-Up TV, 303-248-3806, marcus@wake-up.tv .

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Women’s Health Initiative: New Findings on Big-Three Cancer Rates

Source: BRUCE JANCIN, Internal Medicine News Digital Network

Because breast and lung cancer are the top two causes of cancer mortality in women, these are sobering findings with important clinical implications, Dr. Rowan T. Chlebowski observed at the San Antonio Breast Cancer Symposium.

Hormone Replacement Therapy

The 54% increased risk of death after diagnosis of colorectal cancer in Women’s Health Initiative (WHI) participants who were randomized to combined-hormone therapy rather than placebo was a trend that didn’t achieve statistical significance. But it’s nonetheless a finding that crushes the enthusiasm that greeted an earlier WHI report of a 44% reduction in the incidence of colorectal cancer in combined-hormone therapy users after 5.6 years of follow-up (N. Engl. J. Med. 2004;350:991-1,004).

“One cannot take forward the 44% relative risk reduction in colorectal cancers as being a positive finding,” said Dr. Chlebowski, professor of medicine at the University of California, Los Angeles.

Given the initial observation of fewer colorectal cancers being diagnosed in the combined-therapy arm of the WHI, investigators were quite surprised by the tumor characteristics of these cancers at time of diagnosis: The colorectal cancers arising in the combined-therapy group – although fewer in number – were much higher risk. In all, 76% of them were pathologically staged as regional or metastatic disease, compared with 48% of colorectal cancers in women on placebo, and 59% percent of the colorectal cancers detected in combined-hormone therapy users were lymph node positive, compared with just 29% in placebo-treated controls.

The WHI consisted of two separate National Institutes of Health–funded, randomized trials that profoundly altered the management of menopausal symptoms. In the early 1990s, more than 40% of all postmenopausal women were on hormonal therapy with estrogen alone or in combination with progestin. Following the initial WHI report of multiple adverse effects of estrogen plus progestin, the popularity of hormone therapy dropped off the table.

One WHI study involved 16,608 postmenopausal women aged 50-79 years with an intact uterus who were randomized to estrogen plus progestin or to placebo for a median of 5.6 years. The other study included 10,739 postmenopausal women with prior hysterectomy who were randomized to conjugated equine estrogens alone or placebo for an average of 7.1 years.

In the examination of WHI trends for the big-three (breast, lung, and colorectal) cancers in women, there is a consistent disparity between their relatively modestly increased incidence in dual-hormone therapy users, relative to placebo, and the far larger death rates resulting from these cancers. For example, after 11 years of follow-up, the incidence of breast cancer is up by 25% in the dual-hormone therapy group, relative to placebo. Yet the relative increase in mortality is 96%. Similarly, the incidence of non–small cell lung cancer (NSCLC) was 23% greater in women on combined-hormone therapy than in those on placebo, but the risk of death from NSCLC was 87% greater.

What your Dr. may not tell you

“The greater effect of estrogen and progestin on deaths from breast, lung, and colorectal cancer – [compared with] the effect on incidence – [suggests that] combined-hormone therapy facilitates growth and metastatic spread of established cancers, perhaps mediated by angiogenesis stimulation,” the oncologist said, adding that “in a variety of preclinical models, estrogen and progestin are potent angiogenesis stimulators.”

The investigators’ initial hypothesis was that nearly all the increase in breast cancers associated with combined-hormone therapy would involve estrogen receptor–positive tumors. Not so. In fact, the new analysis – based upon 11 years of follow-up and 678 cases of breast cancer – shows that all breast cancer subtypes appear to be increased, relative to rates in the placebo arm.

For example, combined-hormone therapy was indeed associated with an adjusted 27% greater increase in estrogen receptor–positive breast cancers than with placebo in a multivariate analysis, but it was also associated with a 40% increase in estrogen receptor–negative tumors, compared with controls. Also noteworthy were the combined-therapy group’s adjusted 78% increase in triple-negative cancers, the twofold increase in HER2-overexpressing tumors, and the 37% increase in HER2-negative tumors.

Nearly all the increase in lung cancer deaths associated with dual-hormone therapy resulted from NSCLC. Hormone therapy had no effect upon small cell lung cancer rates.

Among current smokers, the cumulative risk of death from lung cancer was 3.42% in those who used dual-hormone therapy for 5-plus years and 2.39% in placebo-treated controls. In other words, 1 in 100 current smokers who used estrogen plus progestin for 5-plus years experienced an otherwise-avoidable death from NSCLC. Among past smokers, the rate was 1 in 200. These numbers are worth keeping in mind, given that today roughly 15% of U.S. women are current smokers, and 35% are past smokers, Dr. Chlebowski noted.

Turning to the results of the estrogen-alone WHI trial, he pointed out that the therapy had no impact on incidence or death rates from lung or colorectal cancer, relative to placebo, but there was a nonsignificant 20% reduction in the relative risk of breast cancer in the hormone therapy group. This trend for a breast cancer–reduction benefit achieved significance in the nearly 4,500 study participants who were randomized to estrogen alone or placebo 5 years or more following the last menstrual period, where the hormonal therapy group enjoyed a 37% relative risk reduction. Of course, that’s not how hormone therapy is ordinarily employed in clinical practice, the physician pointed out.

One audience member rose to say that the oft-quoted sharply increased risk of uterine cancer in women with an intact uterus on estrogen alone dates back to older studies using doses that were considerably higher than those available in contemporary practice, as well as older methods of patient monitoring. She asked about the possibility of exploring ways to provide estrogen alone to menopausal women with an intact uterus without exposing them to increased uterine cancer risk.

Dr. Chlebowski said he thinks it’s certainly an appropriate research project, but he’d advise against trying it in clinical practice, given the product labeling and the malpractice lawsuit climate.

His take-home message from the expanded WHI analysis: “Even short-term use of combined-hormone therapy should be reserved for women with limiting climacteric symptoms [that are] not manageable by other means.”

In a conference-closing review of the past year’s top developments in early breast cancer, Dr. Alan Coates singled out Dr. Chlebowski’s presentation on the WHI results as hands-down the most important study of the year in the field of cancer epidemiology.

“As we’ve known before, there’s a small but real increase in the incidence of breast cancer with combined-hormone replacement. The new finding is that there’s a massive increase – nearly a doubling – in mortality from breast cancer. And the mortality increase isn’t confined to breast cancer. … This disparate increase in mortality over incidence in several tumor types suggests that the estrogen and progestin [combination] is doing something to the behavior of existing tumors,” commented Dr. Coates of the University of Sydney.

It may be, as Dr. Chlebowski proposed, that the mechanism involves the angiogenic pathway, but other investigators have demonstrated that under certain circumstances, progestagens can stimulate stem cells by a paracrine RANKL (receptor-activated nuclear factor–kappaB ligand) mechanism. This could provide an equally plausible alternative explanation, he said.

Dr. Chlebowski disclosed that he receives grant support from Amgen and is on the speakers bureaus for AstraZeneca and Novartis. Dr. Coates reported having no relevant financial disclosures.

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Scientists in the United Kingdom recently identified a natural alternative cancer treatment that used to be found in abundance in fruits and vegetables. Known as salvestrols, these specific compounds are closely correlated with apoptosis or cancer cell death.

Salvestrol Supplements

These natural nutrients, along with their cofactors, give plant organisms the ability to naturally fight fungus and mold.

In the human body salvestrols attack cancer cells and cause their death. A small group of scientists are currently using different salvestrol formulations to both prevent and cure cancer.

Prior to the advent of modern agricultural practices salvestrols were found in abundance in individual diets. Their purpose in the plant world is to naturally resist mold and fungus.

The advent of hybrids, genetically modified organisms, and modern herbicides has caused fruits and vegetables’ to lose their ability to produce salvestrols in the quantities they once did. This means the plants no longer resist fungus naturally and humans no longer receive enough of these natural nutrients to prevent or cure cancer.

I hasten to add, not without controversy. Much like oleander extract, paw paw, B-17 (laetrile) and other natural cancer fighters that can’t be patented, the discoverers of these cancer fighting abilities are under attack from both pharmaceutical and government sources.

And, there is always the possibility salvestrols may turn out not to be nearly the cancer tool they appear to be. My own personal opinion is they deserve study and use by the alternative community so we can determine their true value.

The following 9 videos have interesting viewpoints on Salvestrol and its anti-cancer effects. They include a 7 part presentation by M.Danny Burke, PhD who, along with Prof. Gerry Potter identified and outlined a nutritional rescue mechanism that linked salvestrols to cancer cell death.

www.youtube.com/watch?v=CFBB17FDD319A649

I am currently in remission and the supplement Salvestrol is new to me so I can’t say from personal experience salvestrols work.  Perhaps a few of you facing active cancer challenges will consider adding them to your regimens and share your results with Pdazzler.com.

In my case, I plan to add Salvestrol to my preventative protocol in place of Laetrile (apricot pits).  Supplemental Laetrile and supplemental Salvestrol are apparently not compatible – source Burke video. I will post my impressions as they are formed. — Pdazzler

Excerpts below from: Nutrition and Cancer: Further Case Studies Involving Salvestrols - Complete article includes case studies of Breast Cancer, Liver Cancer, Colon Cancer, Prostate Cancer and Hodgkin’s Lymphoma. (Here in PDF Format)

Journal of Orthomolecular Medicine
Review Article
Volume 25, Number 1, 2010

Nutrition and Cancer: Further Case Studies Involving Salvestrols

Authors: Brian A. Schaefer, D.Phil.,1 Catherine Dooner, B.A.2 M. Danny Burke, Ph.D.,3 Gerard A. Potter, Ph.D.4 1Corresponding author: Clinical Intelligence Corp., 205-1095 McKenzie Avenue, Victoria, BC Canada V8P 2L5; email: bschaefer@aiinc.ca; 2CARE Technologies Corp.;3Professor Emeritus of Pharmaceutical Metabolism, Salvestrol Natural Products Ltd.; 4Professor, Head of Cancer Drug Discovery Group, De Montfort University, Leicester LE1 9BH, United Kingdom

Abstract

Sources of Salvestrol

A nutritional approach to the treatment of cancer can provide great benefit to patients. The nutritional approach focused on through these cases addresses deficiencies in dietary phytonutrients known as Salvestrols along with their co-factors. Salvestrols operate through a highly targeted mechanism that hinges on their metabolism by the universal cancer marker CYP1B1. This results in a very broadly applicable method in addressing a nutritional deficiency to the benefit of patients. Unfortunately modern farming practices have severely limited the availability of these specific phytonutrients in the modern diet. These phytonutrients are all phytoalexins and are not induced in abundance until the plant comes under attack from infection or predation. Six cases of recovery from cancer using this nutritional approach are discussed. To illustrate the breadth of this approach cases are presented representing five diverse cancers: breast; prostate; colon; liver; and Hodgkin’s lymphoma. Two of the cases show how rapid and dramatic the improvement can be when nutritional deficits are addressed. (Page 2)

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